8th International Symposyum On Adenosine And Adenine Nucleotides

Basic Pharmacology - Chair: E. Lazarowski (Chapel Hill, USA), J. Boyer (Chapel Hill, USA).
Medicinal Chemistry - Chair: A. P. Ijzerman (Leiden, The Netherlands), P. G. Baraldi (Ferrara, Italy).
Basic Pharmacology - Chair: A. Ribeiro (Lisboa, Portugal), M. T. Miras-Portugal (Madrid, Spain).
Medicinal Chemistry - Chair: K. Jacobson (Bethesda, USA), G. Cristalli (Camerino, Italy).
Overview - R. A. North (Manchester, UK).
Cardiovascular System - Chair: L. Belardinelli (Palo Alto, USA), R. Lasley (Lexington, USA).
Bone and Cartilage - Chair: J. A. Gallagher (Liverpool, UK), T. Arnett (London, UK).
Cardiovascular System - Chair: A. Pelleg (Philadelpia, USA), J. Headrick (Brisbane, Australia).
Immunology and Inflammation - Chair: J. Linden (Charlottesville, USA), B. Cronstein (New York, USA).
Platelets - Chair: M. Cattaneo (Milano, Italy), C. Gachet (Strasbourg, France).
Round Table: Caffeine and Health - Chair: B. Fredholm (Stockholm, Sweden), S. Garattini (Milano, Italy), E. Illy (Trieste, Italy).
Overview - S. Robson (Boston, USA).
Respiratory System - Chair: I. Biaggioni (Nashville, USA), L. Belardinelli (Palo Alto, USA).
Immunology and Inflammation - Chair: F. Koch-Nolte (Hamburg, Germany), M. Sitkovsky (Boston, USA).
Berne Award - B. Fredholm (Stockholm, Sweden).
Round Table: Non adenine based purines - Chair: F. Caciagli (Chieti, Italy), M. P. Rathbone (Hamilton, Canada).
Giuliana Fassina Award: L. Belardinelli (Palo Alto, USA).
Overview - J. Linden (Charlottesville, USA).
Cell Proliferation and Cancer - Chair: F. Di Virgilio (Ferrara, Italy), P. Dagnelie (Maastricht, The Netherlands).
Pain and nerve transmission - Chair: K. Inoue (Fukuoka, Japan), P. Illes (Leipzig, Germany).
Cell Proliferation and Cancer - Chair: P. Fishman (Tel Aviv, Israel), P. A. Borea (Ferrara, Italy).
Burnstock Lecture - H. Zimmermann (Frankfurt, Germany).
Adenosine and Neuroprotection - Chair: B. Fredholm (Stocholm, Sweden), J. Fan Chen (Boston, USA).
Ecto-nucleotidases: Structure and function - Chair: M. Bollen (Leuven, Belgium), G. Guidotti (Boston, USA).
Plenary Lecture - G. Burnstock (London, UK).
EctoATPases and Metabolism - Chair: T. L. Kirley (Cincinnati, USA), J. Sevigny (S.te Foy, Canada).
Central Nervous System - Chair: M. P. Abbracchio (Milano, Italy), R. A. Cunha (Coimbra, Portugal).
Ecto-nucleotidases: Physiological implications - Chair: S. Robson (Boston, USA), H. Zimmermann (Frankfurt, Germany).
Overview - P. Illes (Leipzig, Sweden).
Overview - B. Cronstein (New York, USA).
Nucleotide Receptors and Cellular Function - Chair: J. Schrader (Duesseldorf, Germany), E. Schwiebert (Birmingham, USA).
Round Table: Purinome-based drugs - Chair: M. Williams (Philadelpia, USA), S. Bhagwat (San Diego, USA).


Time Table
Wednesday, May 24
	Teatro Comunale - Theatre Hall
14.30 - 15.00	Opening ceremony

	Theatre Hall		The Ridotto
15.00 - 18.20	Symposium - Basic Pharmacology: Invited Lectures.		Symposium - Medicinal Chemistry: Invited Lectures.

	Teatro Comunale - Theatre Hall
18.30 - 19.00	Overview: R.A. North (Manchester, UK)

	Porch of Castello Estense
19.30	Welcome Party


Thursday, May 25
	Theatre Hall		The Ridotto
08.00 - 09.40	Symposium - Cardiovascular System I: Invited Lectures.		Symposium - Bone and cartilage: Invited Lectures.

	Teatro Comunale - Theatre Hall
09.40 - 10.05	Coffee Break

	Theatre Hall	The Ridotto	Ballet Room
10.05 - 11.20	Symposium - Cardiovascular System II: Invited Lectures.	Symposium - Immunology and Inflammation: Invited Lectures.	Round Table - Caffeine and Health (beginning to 10.55).
11.20 - 12.35	Oral Presentations - Basic Pharmacology.

	Teatro Comunale - Theatre Hall
12.40 - 13.10	Overview: S. Robson (Boston, USA)
13.10 - 14.30	Lunch

	Theatre Hall		The Ridotto
14.30 - 16.50	Symposium - Respiratory System: Invited Lectures.		Symposium - Immunology and Inflammation: Invited Lectures (ends to 16.45).

	Teatro Comunale - Theatre Hall
16.50 - 17.15	Coffee Break
17.15 - 18.00	Robert M. Berne Award: B.B. Fredholm (Stockolm, Sweden)

	Theatre Hall		The Ridotto
18.00 - 19.30	Oral Presentations - Respiratory and Cardiovascular Systems.		Oral Presentations - Immunology and Inflammation.

	Castello Estense
08.00 - 19.30	Poster Sessions: 1,2,3,4.

	Teatro Comunale - Theatre Hall
21.30	Concert


Friday, May 26
	Theatre Hall		The Ridotto
08.00 - 09.30	Oral Presentations - Nervous System.		Oral Presentations - Cell Proliferation and Cancer.

	Teatro Comunale - Theatre Hall
09.35 - 10.05	Overview: J. Linden (Charlottesville, USA)
10.05 - 10.35	Coffee Break
10.40 - 11.25	Giuliana Fassina Award: L. Belardinelli (Palo Alto, USA)

	Theatre Hall		The Ridotto
11.30 - 12.45	Symposium - Pain and Nerve Transmission: Invited Lectures.		Symposium - Cell Proliferation and Cancer: Invited Lectures.
13.00 - 14.30	Lunch
14.30 - 16.10	Symposium - Pain and Nerve Transmission: Invited Lectures.		Symposium - Cell Proliferation and Cancer: Invited Lectures.

	Teatro Comunale - Theatre Hall
16.10 - 16.30	Coffee Break
16.40 - 17.25	Geoffrey Burnstock Lecture: H. Zimmermann (Frankfurt, Germany)

	Theatre Hall		The Ridotto
17.30 - 19.30	Oral Presentations - Medicinal Chemistry and Basic Pharmacology.		Round Table - Non-Adenine Based Purines: Invited Lectures.

	Castello Estense
08.00 - 19.30	Poster Sessions: 5,6.

20.30	Social Dinner


Saturday, May 27
	Theatre Hall		The Ridotto
08.00 - 10.05	Symposium - Central Nervous System: Invited Lectures.		Symposium - Ecto-nucleotidases: Structure and Function: Invited Lectures.

	Teatro Comunale - Theatre Hall
10.05 - 10.30	Coffee Break

	Theatre Hall		The Ridotto
10.30 - 12.10	Oral Presentations - Central Nervous System (beginning to 10.40).		Symposium - EctoATPases and metabolism: Invited Lectures.

	Teatro Comunale - Theatre Hall
12.15 - 13.00	Plenary Lecture: G. Burnstock (London, UK)
13.00 - 14.30	Lunch

	Theatre Hall		The Ridotto
14.30 - 16.35	Symposium - Adenosine and Neuroprotection: Invited Lectures.		Symposium - Ecto-nucleotidases: Physiological Implications: Invited Lectures.

	Teatro Comunale - Theatre Hall
16.35 - 16.55	Coffee Break
17.00 - 17.30	Overview: P. Illes (Leipzig Germany)

	Theatre Hall		The Ridotto
17.40 - 18.25	Oral Presentations - Central Nervous System.		17.40 - 18.55 Symposium - Platelets: Invited Lectures.
18.30 - 19.30	Oral Presentations - Basic and Applied Pharmacology.		19.00 - 19.45 Oral Presentations - Basic and Applied Pharmacology.

	Castello Estense
08.00 - 19.30	Poster Sessions: 7,8,9,10.


Sunday, May 28
	Theatre Hall		The Ridotto
08.00 - 10.00	Oral Presentations - Clinical Pharmacology.		19.00 - 19.45 Oral Presentations - Basic and Applied Pharmacology.

	Teatro Comunale - Theatre Hall
10.00 - 10.20	Coffee Break
10.20 - 10.50	Overview: B. Cronstein (New York, USA)

	Theatre Hall		The Ridotto
10.50 - 12.55	Symposium - Nucleotide Receptors and Cellular Function.		Round Table - Purinome-based drugs.

	Teatro Comunale - Theatre Hall
13.00 - 13.10	Concluding Remarks
13.10 - 14.30	Lunch



Detailed programme
Wednesday, May 24
	Theatre Hall
14.30 - 15.00	Opening ceremony

	Theatre Hall		The Ridotto
	Basic Pharmacology - Chair: E. Lazarowski, J. Boyer.		Medicinal Chemistry - Chair: A.P. Ijzerman, P.G. Baraldi.
15.00 - 15.25	M. Diaz-Hernandez - Modulation of presynaptic P2X receptors by other neurotransmitter systems.		A. P. Ijzerman - Novel orthosteric and allosteric ligands for adenosine receptors.
15.25 - 15.50	M. Idzkò - P2-Receptor mediated immune-responses: a link to asthmatic airway inflammation?		P. G. Baraldi - Recent developments in A_2B and A₃ adenosine receptor antagonists.
15.50 - 16.15	R. J. Evans - Molecular physiology and pharmacology of P2X₁ receptors.		J. Zablocki - The discovery of selective high affinity A_2B adenosine receptor antagonists.
16.15 - 16.40	E. Lazarowski - Release of nucleotides and UDP-sugars from airway epithelia.		M. Botta - Synthesis and molecular modeling studies of new pyrazolo[3,4-b]pyridines, potent and selective inhibitors of A₁ adenosine receptors.
	Basic Pharmacology - Chair: A. Ribeiro, M. T. Miras-Portugal.		Medicinal Chemistry - Chair: K.A. Jacobson, G. Cristalli.
16.40 - 17.05	J.Pintor - Role of diadenosine polyphosphates on corneal wound healing.		K. A. Jacobson - Molecular recognition in P2Y nucleotide receptors.
17.05 - 17.30	A. Surprenant - New insight into P2X₇ receptor signaling.		G. Cristalli - New nucleotides and nucleotides analogs and their activity on P2 Receptors.
17.30 - 17.55	G. A. Weisman - Novel Signal Transduction Pathways Regulated by P2Y₂ Nucleotide Receptors Mediate Inflammatory Responses in Mammalian Cells.		C. E. Muller - Development of pharmacological tools for studying P2Y receptors.
17.55 - 18.20	T. K. Harden - Quantification and agonist-promoted regulation of the P2Y₁ receptor.		P. S. Watson - Adenine nucleotides as reversible P2Y₁₂ antagonists.

	Theatre Hall
	Overview: Chair: F. Di Virgilio
18.30 - 19.00	R. A. North - Structure and function of P2X receptors.

	Porch of Castello Estense
19.30	Welcome Party


Thursday, May 25
	Theatre Hall		The Ridotto
	Cardiovascular System I - Chair: L. Belardinelli, R. D. Lasley.		Bone and cartilage - Chair: J. A. Gallagher, T. Arnett.
08.00 - 08.25	L. Kuo - Adenosine and vasomotor regulation in the coronary microcirculation.		J. A. Gallagher - Integrating local and systemic regulation of bone turnover though P2 receptor signalling.
08.25 - 08.50	T. H. Adair - An emerging role for adenosine in angiogenesis.		T. Arnett - P2Y nucleotide receptor function in osteoblasts.
08.50 - 09.15	G. A. Rongen - The forearm model as a tool to study the clinical pharmacology of adenosine in humans.		S. J. Dixon - P2X₇ nucleotide receptor functions in bone cells.
09.15 - 09.40	R. D. Lasley - Subcellular aspects of adenosine receptor-mediated signaling in ventricular myocardium.		N. R. Jorgensen - The role of nucleotides and P2 receptors in intercellular signaling in bone.
09.40 - 10.05	Coffee Break		Coffee Break
	Cardiovascular System II - Chair: A. Pelleg, J. Headrick.		Immunology and Inflammation - Chair: J. Linden, B. Cronstein.
10.05 - 10.30	A. Deussen - Control of extracellular adenosine concentration by ecto-5' nucleotidase.		E. Chan - Adenosine in dermal and hepatic fibrosis.
10.30 - 10.55	S. J. Mustafa - Molecular mechanisms of coronary flow regulation by adenosine.		M. Sitkovsky - From "Hellstrom paradox" to Redox-Adenosinergic Rule of Immune Response.
10.55 - 11.20	R. Rosso - Use of adenosine compounds for identifying patients prone to suffer from tachyarrhythmias.	Ballet Room Round Table on Caffeine and Health - Chair: B. Fredholm, S. Garattini, E. Illy.	M. R. Blackburn - Adenosine receptors and the regulation of chronic lung disease.
	Basic Pharmacology - F. Caciagli, J. Boyer.	Opening Remarks: S. Garattini. Discussants: W. R. Lovallo -Caffeine effects on blood pressure and stress responses in persons at risk for developing hypertension. A. Nehlig - Caffeine and headache: an update. J. M. Vaugeois, M. El. Yacoubi - The effects of caffeine on anxiety- and mood-related behaviors in mice. Closing Remarks: S. Garattini, B.B. Fredholm, E. Illy.
11.25 - 11.50	Oral Presentations		M. D. Okusa - Adenosine A_2A agonists in renal tissue protection.
11.50 - 12.15			J. D. Powell - Tissue-derived adenosine promotes peripheral T cell tolerance by Stimulating the A_2A receptor.
12.15 - 12.35

	Theatre Hall
	Overview: Chair: H. Zimmerman
12.40 - 13.10	Simon Robson - The ecto-nucleotidase CD39/NTPDase1 is a key modulator of vascular inflammation and immunity.

13.10 - 14.30	Lunch

	Theatre Hall		The Ridotto
	Respiratory System - Chair: I. Biaggioni, L. Belardinelli.		Immunology and Inflammation - Chair: F. Koch-Nolte, M. Sitkovsky.
14.30 - 14.40	L. Belardinelli - Opening remarks.
14.40 - 15.05	I. Feoktistov - Role of adenosine receptors in regulation of pro-inflammatory and pro-angiogenic cytokines in mast cells.		J. S. Wiley - Polymorphisms in the P2X₇ receptor and their clinical associations.
15.05 - 15.30	D. Zeng - Inflammatory role of adenosine in human lung cells.		R. Coutinho-Silva - P2 receptors: Role on host defense against intracellular microorganisms.
15.30 - 15.55	R. C. Boucher - Airway epithelial ATP release and airway surface hydration in health and disease.		F. Koch-Nolte - Activation of P2X₇ by ADP-ribosylation.
15.55 - 16.20	S. P. Colgan - Coordinated nucleotide metabolism and vascular leak.		D. Communi - Target genes of extracellular ATP in human dendritic cells.
16.20 - 16.45	R. Polosa - Adenosine: a promising clinical indicator of inflammation in asthma.		M. Seman - ADP-ribosylation by ARTs introduces diacritic modifications in the cytokine network.
16.45 - 16.50	I. Biaggioni - Closing remarks.
16.50 - 17.15	Coffee Break		Coffee Break

	Theatre Hall
	Berne Award - Chair: J. Linden.
17.15 - 18.00	B. B. Fredholm - Targeting adenosine receptors.

	Theatre Hall		The Ridotto
	Respiratory and Cardiovascular Systems - Chair: C. N. Wilson, S. J. Mustafa.		Immunology and Inflammation - Chair: F. Haag, J. Auchampach.
18.00 - 19.40	Oral presentations		Oral presentations

	Theatre Hall
21.30	Social Event: Gino Neri Orchestra (Typical Italian Music). Site web


Friday, May 26
	Theatre Hall		The Ridotto
	Nervous System - Chair: C. Volontè, M. Morelli.		Cell Proliferation and Cancer - Chair: A. Minelli, L. Erb.
08.00 - 09.30	Oral presentations		Oral presentations

	Theatre Hall
	Overview - Chair: M. Sitkowski.
09.35 - 10.05	Joel Linden - Activation of adenosine A_2A receptors on CD4⁺ T cells reduces reperfusion injury.
10.05 - 10.35	Coffee Break
	Giuliana Fassina Award - Chair: P. A. Borea.
10.40 - 11.25	Luiz Belardinelli - Therapeutic potential of partial A₁ agonists in insulin resistance and diabetes.

	Theatre Hall		The Ridotto
	Pain and Nerve Transmission - Chair: K. Inoue, P. Illes.		Cell Proliferation and Cancer - Chair: F. Di Virgilio, P. Dagnelie.
11.30 - 11.55	K. Inoue - P2X₄-dependent neuropathic pain: a mechanism of the facilitation in pain transmission via microglia.		P. Dagnelie - ATP: a new treatment modality in cancer?
11.55 - 12.20	A. Nistri - Expression, function and modulation of P2X₃ receptors on trigeminal ganglion nociceptors.		F. Di Virgilio - P2X₇: a growth-promoting receptor.
12.20 - 12.45	I. P. Chessel - The role of P2X₇ and P2X₄ in pain processing: common or divergent pathways?		J. T. Neary - Regulation of astrocyte proliferation by P2Y and P2X purinergic receptors.

13.00 - 14.30	Lunch

	Theatre Hall		The Ridotto
	Pain and Nerve Transmission - Chair: K. Inoue, P. Illes.		Cell Proliferation and Cancer - Chair: P. Fishman, P. A. Borea.
14.30 - 14.55	K. Biber - Adenosine receptors in astrocytes, cytokines and neuroprotection.		P. Fishman - Targeting the A₃ adenosine receptor to combat cancer and autoimmune inflammatory diseases.
14.55 - 15.20	C. Verderio - Functional consequences of P2X₇ activation in astrocytes and microglial cells.		S. Bar-Yehuda - Inhibition of hepatocellular carcinoma growth by an A₃ adenosine receptor agonist: De-regulation of PKB/Akt-NF-kB signaling pathway.
15.20 - 15.45	A. M. F. Sebastiao - Adenosine regulation of neurotrophin synaptic actions.		Lak Shin Jeong - Design, synthesis and antitumor activity of 4'-thionucleosides as highly potent and selective A₃ adenosine receptor agonists.
15.45 - 16.10	S. Kohsaka - Intracellular signalling underlying ATP-induced chemotaxis of microglia.		S. Merighi - Growth regulation of tumor cells in hypoxia: focus on A₃ adenosine receptors.
16.10 - 16.30	Coffee Break		Coffee Break

	Theatre Hall
	Burnstock Lecture - Chair: G. Burnstock
16.40 - 17.25	Herbert Zimmermann - Versatile messengers in the brain: nucleotide storage, signaling and hydrolysis.

	Theatre Hall		The Ridotto
	Medicinal Chemistryand Basic Pharmacology - Chair: S. Vittori, G. Reiser.		Round Table on Non-Adenine Based Purines - Chair: F. Caciagli, M. P. Rathbone.
17.30 - 17.50	Oral presentations		M. P. Rathbone - Evidence for a patho-physiological and pharmacological role of guanine-based purines as a new extracellular signalling system.
17.50 - 18.10			D. O. Souza - The guanine-based purinergic system as a new target for neuroprotection against glutamatergic excitotoxicity.
18.10 - 18.30			S. Jiang - Guanosine stimulates remyelination in injured spinal cord through promotion of proliferation and differentiation of oligodendroglial precursor cells.
18.30 - 18.50			P. L. Ipata - The role of uridine kinase and uridine phosphorylase in the cross regulation of uracil and adenine nucleotides salvage synthesis in rat and human brain.
18.50 - 19.10			G. G. Yegutkin - Metabolism of extracellular nucleotides and nucleosides in the vasculature.
19.10 - 19.30			F. Caciagli - Towards a patho-physiological role of non adenine purine nucleobases in the Central Nervous System.

20.30	Social Dinner


Saturday, May 27
	Theatre Hall		The Ridotto
	Central Nervous System - Chair: M. P. Abbracchio, R. A. Cunha.		Ecto-nucleotidases: Structure and Function - Chair: M. Bollen, G. Guidotti.
08.00 - 08.25	M. Abbracchio - P2 receptors in glial cells.		G. Guidotti - The transmembrane domains of E-NTPDase 1, CD39, regulate its enzymatic activity.
08.25 - 08.50	R. A. Cunha - Presynaptic P₂ receptors - Interaction with other receptors and role in neuroprotection.		T. L. Kirley - Progress on the structures and functions of nucleoside triphosphate diphosphohydrolases and a calcium activated nucleotidase.
08.50 - 09.15	R. D. Fields - Purinergic signaling in regulating myelination by action potentials.		M. Bollen - Contibution of NPP-type ectophosphodiesterases to extracellular nucleotide metabolism.
09.15 - 09.40	P. Haydon - Purinergic coordination of synaptic cross-talk mediated by astrocytes.		M. Takedachi - CD73-deficient mice show increased lymphocyte migration through high endothelial venules (HEV) in draining lymph nodes during inflammation.
09.40 - 10.05	L. Galliresta - Extracellular ATP mediates rapid retinal ganglion cell injury induced by intraocular pressure spikes.
10.05 - 10.30	Coffee Break		Coffee Break
	Central Nervous System - Chair: F. Pedata, P. Popoli.		EctoATPases and Metabolism - Chair: T. L. Kirley, J. Sevigny.
10.30 - 10.55	Oral Presentations		J. Sevigny - Co-ordinated regulation of P2-receptors signaling by membrane bound NTPDases.
10.55 - 11.20			J. Straeter - Structure and function of ecto-5'-nucleotidase based on structural studies of the bacterial 5'-nucleotidases.
11.20 - 11.45			J. L. Millàn - The key regulators of skeletal mineralization: TNAP, NPP1 and ANK as therapeutic targets for the treatment of osteoarthritis, hypophosphatasia and arterial calcification.
11.45 - 12.10			S. P. Colgan - Ecto-5’-nucleotidase (CD73) and mucosal inflammation.

	Theatre Hall
	Plenary Lecture - Chair: F. Di Virgilio.
12.10 - 12.55	Geoffrey Burnstock - Purinergic signalling: past, present and future

13.00 - 14.30	Lunch

	Theatre Hall		The Ridotto
	Adenosine and neuro protection - Chair: B. B. Fredholm, J. F - Chen.		Ecto-nucleotidases: Physiological Implications - Chair: S. Robson, H. Zimmermann.
14.30 - 14.55	J. F. Chen - Adenosine A_2A receptors modulate psychomotor activity and brain injury by distinct cellular mechanisms.		S. Deaglio - Ectoenzymes of CD38 and CD39 gene families catalyze immunomodulation.
14.55 - 15.20	R. Franco - Adenosine receptor-receptor interactions: relevance for ischemia and caffeine tolerance.		F. Malavasi - CD38/CD157 gene family in health and disease.
15.20 - 15.45	Y. Chern - Adenosine and Huntington's disease.		J. Schrader - Role of CD73-derived adenosine in acute and chronic inflammation.
15.45 - 16.10	T. Kanda - Adenosine A_2A receptors and Parkinson's disease - Effects of Istradefylline on functional models of Parkinson’s disease.		M. Picher, L. H. Burch - Biphasic regulation of airway E-NTPDases by "Pseudomonas Aeruginosa" Lipopolysaccharide.
16.10 - 16.35	I. Diamond - A_2A adenosine receptors regulate CNS responses to ethanol and addicting substances: recent advances from cell biology to behavior.		D. J. Pinsky - to be announced.
16.35 - 16.55	Coffee Break		Coffee Break

	Theatre Hall
	Overview - Chair: A. North.
17.00 - 17.30	Peter Illes - P2X and P2Y receptor-involvement in pain sensation; possible targets for new analgesics.

	Theatre Hall		The Ridotto
	Central Nervous System - Chair: C. Verderio, R. Ciccarelli.		Platelets - Chair: M. Cattaneo, C. Gachet.
17.40 - 18.05	Oral Presentations		M. Cattaneo - Congenital and drug-induced P2Y₁₂ defects in the clinical setting.
18.05 - 18.30			C. Gachet - P2Y₁ and P2X₁ as targets for new anti-platelet agent.
	Basic and Applied Pharmacology - Chair: J. Pintor, U. Traversa.
18.30 - 18.55	Oral Presentations		M. Mahaut-Smith - Purinoceptor-evoked signalling via P2X₁ and other ion channels in the platelet.
18.55 - 19.30			Basic and Applied Pharmacology - Chair: S. Ceruti, E. Kaczmarek.
19.00 - 19.45			Oral Presentations


Sunday, May 28
	Theatre Hall		The Ridotto
	Clinical Pharmacology - Chair: D. Spina, B. Hechler.		Basic and Applied Pharmacology - Chair: C. Martini, S. Hourani.
08.00 - 10.00	Oral Presentations		Oral Presentations
10.00 - 10.20	Coffee Break		Coffee Break

	Theatre Hall
	Overview - Chair: M. P. Abbracchio.
10.20 - 10.50	Bruce Cronstein - A Fuller Quiver - Adenosine receptors as therapeutic targets.

	Theatre Hall		The Ridotto
	Nucleotide Receptors and Cellular Function - Chair: J Schrader, E. Schwiebert.		Round Table: Purinome-based drugs - Chair: M. Williams, S. Bhagwat.
10.50 - 11.15	J. Jankowski - Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor..		Discussants: Steve Hall - Beyond purinergic receptors: drugging the rest of the purine-binding proteome. Alan J. Lewis - Kinases: important drug targets for novel anti-inflammatory therapies. Carlos Garcia-Echeverria - Challenges and opportunities in the identification of insulin-like growth factor-I receptor kinase inhibitors. David G. Barrett - Allosteric activators of glucokinase: the development of cyclopropane-derived agents and their potential for use in the treatment of type two diabetes.
11.15 - 11.40	E. M. Schwiebert - Co-secretion and autocrine signaling of ATP, zinc and other mediators in epithelial and non-epithelial cell models: dynamic and minute-to-minute regulation of cell physiology.
11.40 - 12.05	I. Novak - P2Y and P2X receptors and their role in exocrine pancreas.
12.05 - 12.30	D. Erlinge - Cardiovascular ATP release: Focus on the red blood cell.
12.30 - 12.55	N. Dale - Purinergic signalling triggers development of the eye.

	Theatre Hall
13.00 - 13.10	Concluding Remarks - P. A. Borea.

13.10 - 14.30	Lunch


Poster sessions will be held in Castello Estense like described in Time Table.